Regulation of EGF-Stimulated EGF Receptor Endocytosis During M Phase
نویسندگان
چکیده
منابع مشابه
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
Although many proteins have been shown to participate in ligand-stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocytic machinery remains elusive. We show here that EGF stimulates transient tyrosine phosphorylation of Tom1L1 by the Src family kinases, resulting in transient interaction of Tom1L1 with the activated EGFR brid...
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© 2012 Wang, licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mutual Regulation of Receptor-Mediated Cell Signalling and Endocytosis: EGF Receptor System as...
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The human epidermal growth factor receptor (EGFR) is a key representative of tyrosine kinase receptors, ubiquitous actors in cell signaling, proliferation, differentiation, and migration. Although the receptor is well-studied, a central issue remains: How does the compositional diversity and functional diversity of the surrounding membrane modulate receptor function? Reconstituting human EGFR i...
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ژورنال
عنوان ژورنال: Traffic
سال: 2010
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2010.01141.x